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Three of the most widely used serotonin supplements are the amino acids tryptophan, 5-HTP, and SAM-e.Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).Do so only if you are working with a knowledgeable health care professional. Tryptophan: Tryptophan might seem like a logical serotonin supplement to try first since tryptophan is a precursor of serotonin.

Here are a few that are integrally connected to serotonin production.

Elsewhere in Europe, it’s available as a prescription drug (8).

Unfortunately, this supplement’s usefulness for depression may be more hype than substance.

Within a few months, this inevitably causes a cascade of negative side effects (10). Datis Kharrazian, author of , lists these co-factors as needed for the synthesis of either tryptophan or 5-HTP to serotonin — vitamins B3, B6, and B12, folic acid, and magnesium.

Look either for serotonin boosting supplements that contain these along with the main active ingredients or add them separately with a high-quality multivitamin mineral supplement.

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